文部科学省 科学研究費補助金

原著  Original Articles

Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, Inoue J.

HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polybiquitin Chains.

PLoS Pathog. 13:e1006162. 2017

 

Nishina T, Deguchi Y, Miura R, Yamazaki S, Shinkai Y, Kojima Y, Okumura K, Kumagai Y, Nakano H.

Critical contribution of NRF2 to an electrophile-induced interleukin-11 production.

J. Biol. Chem. 292: 205-16, 2017

 

Piao X, Yamazaki S, Komazawa-Sakon S, Miyake S, Nakabayashi O, Kurosawa K, Mikami T, Tanaka M, Van Rooijen N, Ohmuraya M, Oikawa A, Kojima Y, Kakuta S, Uchiyama Y, Tanaka M, Nakano H.

Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum.

Hepatology 65: 237-52, 2017

 

Nagata S, Tanaka M.

Programmed cell death and the immune system.

Nat. Rev. Immunol. 17: 333-340. 2017

 

Nakano H, Piao X, Shindo R, Komazawa-Sakon S.

Cellular FLICE-Inhibitory Protein Regulates Tissue Homeostasis.

Curr. Top Microbiol Immunol. 403:119-41. 2017

 

Yagai T, Matsui S, Harada K, Inagaki FF, Saijou E, Miura Y, Nakanuma Y, Miyajima A, Tanaka M.

Expression and localization of sterile alpha motif domain containing 5 is associated with cell type and malignancy of biliary tree.

PLoS One. 12: e0175355. 2017.

 

Miyazawa H, Yamaguchi Y*, Sugiura Y, Honda K, Kondo K, Matsuda F, Yamamoto T, Suematsu M, Miura M*. *Co-corresponding Author.

Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching.

Development 144: 63-73. 2017

 

Taki K, Hashimoto D, Nakagawa S, Ozaki N, Tomiyasu S, Ohmuraya M, Arima K, Kaida T, Higashi T, Sakamoto K, Sakata K, Okabe H, Nitta H, Hayashi H, Chikamoto A, Beppu T, Takamori H, Hirota M, Baba H.

Significance of lymph node metastasis in pancreatic neuroendocrine tumor.

Surg. Today. Feb 22. 2017

 

Yagi T, Hashimoto D, Taki K, Yamamura K, Chikamoto A, Ohmuraya M, Beppu T, Baba H.

Surgery for metastatic tumors of the pancreas.

Surg. Case Rep. 3: 31. 2017

 

Kato Y, Furusyo N, Tanaka Y, Ueyama T, Yamasaki S, Murata M, Hayashi J.

The Relation between Serum Endostatin Level and Carotid Atherosclerosis in Healthy

Residents of Japan: Results from the Kyushu and Okinawa Population Study (KOPS).

Atheroscler. Thromb. 2017 Apr 20.

 

Nagata M, Izumi Y, Ishikawa E, Kiyotake R, Doi R, Iwai S, Omahdi Z, Yamaji T, Miyamoto T, Bamba T, Yamasaki S.

Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity.

Proc. Natl. Acad. Sci. USA. 114: E3285-E3294. 2017

 

Kottom TJ, Hebrink DM, Jenson PE, Nandakumar V, Wüthrich M, Wang H, Klein B, Yamasaki S, Lepenies B, Limper AH.

The Interaction of Pneumocystis with the C-Type Lectin Receptor Mincle Exerts a Significant Role in Host Defense against Infection.

J. Immunol. 198: 3515-25. 2017

 

Mori D, Shibata K, Yamasaki S.

C-Type Lectin Receptor Dectin-2 Binds to an Endogenous Protein β-Glucuronidase on Dendritic Cells.

PLoS One 12: e0169562. 2017

 

Ishikawa E, Mori D, Yamasaki S.

Recognition of Mycobacterial Lipids by Immune Receptors.

Trends Immunol. 38:66-76. 2017

 

Ishimoto T, Ninomiya K, Inoue R, Koike M, Uchiyama Y, Mori H.

Mice lacking BCAS1, a novel myelin-associated protein, display hypomyelination, schizophrenia-like abnormal behaviors, and upregulation of inflammatory genes in the brain.

Glia. 65: 727-39. 2017

 

Niizeki H, Hayashi R, Naiki Y, Yoshida K, Tanaka R, Shimizu A, Terashima H, Isogawa N, Abe R, Shimomura Y.

Delayed-onset heat intolerance in a Japanese patient with X-linked hypohidrotic ectodermal dysplasia associated with a large deletion involving four genes.

J. Dermatol. Apr 26. 2017

 

Sato K, Shinkuma S, Fujimoto K, Hatanaka KC, Ujiie H, Nomura T, Fujita Y, Abe R, Matsuno Y, Shimizu H.

Late-onset skin involvement on the forehead in multicentric Castleman disease.

Int. J. Dermatol. Feb 27. 2017

 

Kabata Y, Shimomura Y, Matsuo Y, Fujiwara H, Abe R.

Photodynamic therapy with intradermal application of 5-aminolevulinic acid successfully improved tumor lesions of mycosis fungoides.

Int. J. Dermatol. 56: e81-e82. 2017

 

Ujiie I, Fujita Y, Nakayama C, Matsumura W, Suzuki S, Shinkuma S, Nomura T, Abe R, Shimizu H.

Altered balance of epidermis-related chemokines in epidermolysis bullosa.

J. Dermatol. Sci. 86:37-45. 2017

 

Deguchi T, Shimomura Y, Hayashi R, Orime M, Tomiyama K, Abe R.

Cross-reactivity of cephalosporins: allergic immediate hypersensitivity to ceftriaxone in a cefcapene pivoxil-sensitized patient.

Eur. J. Dermatol. 27:187-9. 2017

 

Orime M, Tomiyama K, Hashidate H, Yoshida S, Hokari S, Tsuda A, Yokoyama H, Narita JI, Uchida Y, Kanekura T, Abe R, Ishii N, Hashimoto T, Kawai K.

Non-paraneoplastic autoimmune subepidermal bullous disease associated with fatal bronchiolitis obliterans.

J. Dermatol. 44: 461-4. 2017

 

Tomii K, Shimomura Y, Fujikawa H, Kariya N, Abe R.

Case of infantile digital fibromatosis: Observation of its dermoscopic features.

J. Dermatol. 44: 549-51. 2017

 

Hayashi R, Yoshida K, Abe R, Niizeki H, Shimomura Y.

First Japanese case of congenital generalized hypertrichosis with a copy number variation on chromosome 17q24.

J. Dermatol. Sci. 85:63-5. 2017

 

Kibune N, Shimomura Y, Hasegawa A, Saeki T, Umemori Y, Abe R.

Beneficial effect of hydroxychloroquine on cutaneous vasculitis in a Japanese patient with systemic lupus erythematosus.

J. Dermatol. 44: e52-e53. 2017

 

Ansai O, Fujikawa H, Shimomura Y, Abe R.

Case of severe acneiform eruptions associated with the BRAF inhibitor vemurafenib.

J. Dermatol. 44: e15-e16. 2017

 

Yoshimoto N, Shinkuma S, Ujiie H, Nomura T, Fujita Y, Abe R, Shimizu H.

Hypertrophic lupus erythematosus successfully treated with hydroxychloroquine.

J. Dermatol. 44:e48-e49. 2017

 

Shibagaki S, Tahara-Hanaoka S, Hiroyama T, Nakamura Y, Shibuya A.

Long-term survival of the mouse ES cell-derived mast cell, MEDMC-BRC6, in mast cell-deficient Kitw-sh/w-sh mice.

Int. Immunol. Apr 18. 2017

 

Eri T, Kawahata K, Kanzaki T, Imamura M, Michishita K, Akahira L, Bannai E, Yoshikawa N, Kimura Y, Satoh T, Uematsu S, Tanaka H, Yamamoto K.

Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1+CXCR5-/dim B-helper T cell induction.

Sci. Rep. 7: 46037. 2017

 

Ansai O, Shimomura Y, Fujimoto A, Sakai A, Tsuchida Y, Hayashi R, Shigehara Y, Hama N, Abe R.

Case of pemphigus herpetiformis with immunoglobulin G autoantibodies against desmocollin-3.

J. Dermatol. 44: 104-5. 2017

 

Kawano Y, Fukui C, Shinohara M, Wakahashi K, Ishii S, Suzuki T, Sato M, Asada N, Kawano H, Minagawa K, Sada A, Furuyashiki T, Uematsu S, Akira S, Uede T, Narumiya S, Matsui T, Katayama Y.

G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2.

Blood 129:587-97. 2017

 

Fukushima T, Yoshihara H, Furuta H, Hakuno F, Iemura SI, Natsume T, Nakatsu Y, Kamata H, Asano T, Komada M, Takahashi SI.

USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.

Biochem. Biophys. Res. Commun. 484: 522-8. 2017

 

Hattori T, Kaji M, Ishii H, Jureepon R, Takarada-Iemata M, Minh Ta H, Manh Le T, Konno A, Hirai H, Shiraishi Y, Ozaki N, Yamamoto Y, Okamoto H, Yokoyama S, Higashida H, Kitao Y, Hori O.

CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously.

Glia. 65:974-89. 2017

 

Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, Takeuchi O, Kawai T, Shimizu S, Matsuura Y, Akira S, Saitoh T.

Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response.

Proc. Natl. Acad. Sci. USA. 114: 2681-6. 2017

 

Ori D, Murase M, Kawai T.

Cytosolic nucleic acid sensors and innate immune regulation.

Int. Rev. Immunol. 36: 74-88. 2017

 

Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, Takeuchi O, Kawai T, Shimizu S, Matsuura Y, Akira S, Saitoh T.

Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response.

Proc. Natl. Acad. Sci. USA. 114: 2681-6. 2017

 

Kitai Y, Kawasaki T, Sueyoshi T, Kobiyama K, Ishii KJ, Zou J, Akira S, Matsuda T, Kawai T.

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity.

J. Immunol. 198: 1649-59. 2017

 

Sakamoto S, Nagamitsu R, Yusakul G, Miyamoto T, Tanaka H, Morimoto S.

Ultrasensitive immunoassay for monocrotaline using monoclonal antibody produced by N, N’-carbonyldiimidazole mediated hapten-carrier protein conjugates.

Talanta 168: 67-72. 2017

 

Sakamoto S, Yusakul G, Tsuneura Y, Putalun W, Usui K, Miyamoto T, Tanaka H, Morimoto S.

Sodium periodate-mediated conjugation of harringtonine enabling the production of a highly specific monoclonal antibody, and the development of a sensitive quantitative analysis method.

Analyst 142: 1140-8. 2017

 

Sakamoto S, Yusakul G, Nuntawong P, Kitisripanya T, Putalun W, Miyamoto T, Tanaka H, Morimoto S. Development of an indirect competitive immunochromatographic strip test for rapid detection and determination of anticancer drug, harringtonine.

J. Chromatogr. B Analyt Technol. Biomed. Life Sci. 1048: 150-4. 2017

 

Champy AS, Mitaine-Offer AC, Miyamoto T, Tanaka C, Papini AM, Lacaille-Dubois MA. Structural analysis of oleanane-type saponins from the roots of Wisteria frutescens.

Magn. Reson. Chem. 55: 595-600. 2017

 

Passman AM, Low J, London R, Tirnitz-Parker JE, Miyajima A, Tanaka M, Strick-Marchand H, Darlington GJ, Finch-Edmondson M, Ochsner S, Zhu C, Whelan J, Callus BA, Yeoh GC.

A Transcriptomic Signature of Mouse Liver Progenitor Cells.

Stem Cells Int.2016: 5702873. 2016

 

Zhang P, Tsuchiya K, Kinoshita T, Kushiyama H, Suidasari S, Hatakeyama M, Imura H, Kato N, Suda T.

Vitamin B6 Prevents IL-1β Protein Production by Inhibiting NLRP3 Inflammasome Activation.

J. Biol. Chem. 291: 24517-27. 2016

 

Yoshikawa Y, Emi M, Hashimoto-Tamaoki T, Ohmuraya M, Sato A, Tsujimura T, Hasegawa S, Nakano T, Nasu M, Pastorino S, Szymiczek A, Bononi A, Tanji M, Pagano I, Gaudino G, Napolitano A, Goparaju C, Pass HI, Yang H, Carbone M.

High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma.

Proc. Natl. Acad. Sci. USA. 113: 13432-7. 2016

 

Kunii M, Ohara-Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, Shimizu T, Simizu S, Lin B, Nunomura K, Aoyagi K, Ohno M, Ohmuraya M, Sato T, Yoshimura SI, Sato K, Harada R, Kim YJ, Osada H, Nemoto T, Kasai H, Kitamura T, Nagamatsu S, Harada A.

Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells.

J. Cell Biol. 215: 121-38. 2016

 

Hashimoto D, Chikamoto A, Taki K, Arima K, Yamashita Y, Ohmuraya M, Hirota M, Baba H.

Residual total pancreatectomy: Short- and long-term outcomes.

Pancreatology 16: 646-51. 2016

 

Watanabe Y, Honda S, Konishi A, Arakawa S, Murohashi M, Yamaguchi H, Torii S, Tanabe M, Tanaka S, Warabi E, Shimizu S.

Autophagy controls centrosome number by degrading Cep63.

Nat Commun. 7: 13508. 2016

 

Torii S, Yoshida T, Arakawa S, Honda S, Nakanishi A, Shimizu S. Identification

of PPM1D as an essential Ulk1 phosphatase for genotoxic stress-induced autophagy.

EMBO Rep. 17: 1552-64. 2016

 

Paudel MK, Sakamoto S, Huy LV, Tanaka H, Tomofumi M, Akihito T, Morimoto S.

Development of an immunoassay using an anti-wogonin glucuronide monoclonal antibody.

J. Immunoassay Immunochem. Dec 27. 2016

 

Ando J, Asanuma M, Dodo K, Yamakoshi H, Kawata S, Fujita K, Sodeoka M. Alkyne-tag SERS screening and identification of small-molecule-binding sites in protein.

J. Am. Chem. Soc. 138: 13901-10. 2016

 

Behler-Janbeck F, Takano T, Maus R, Stolper J, Jonigk D, Tort Tarrés M, Fuehner T, Prasse A, Welte T, Timmer MS, Stocker BL, Nakanishi Y, Miyamoto T, Yamasaki S, Maus UA.

C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia.

PLoS Pathog. 12: e1006038. 2016

 

Iborra S, Martínez-López M, Cueto FJ, Conde-Garrosa R, Del Fresno C, Izquierdo HM, Abram CL, Mori D, Campos-Martín Y, Reguera RM, Kemp B, Yamasaki S, Robinson MJ, Soto M, Lowell CA, Sancho D.

Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection.

Immunity 45:788-801. 2016

 

van der Peet PL, Nagata M, Shah S, White JM, Yamasaki S, Williams SJ.

Lipid structure influences the ability of glucose monocorynomycolate to signal through Mincle.

Org. Biomol. Chem. 14: 9267-77. 2016

 

Kimura Y, Inoue A, Hangai S, Saijo S, Negishi H, Nishio J, Yamasaki S, Iwakura Y, Yanai H, Taniguchi T. The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.

Proc. Natl. Acad. Sci. USA. 113:14097-102. 2016

 

Zhou H, Yu M, Zhao J, Martin BN, Roychowdhury S, McMullen MR, Wang E, Fox PL, Yamasaki S, Nagy LE, Li X. IRAKM-Mincle axis links cell death to inflammation: Pathophysiological implications for chronic alcoholic liver disease.

Hepatology 64:1978-93. 2016

 

Clément M, Basatemur G, Masters L, Baker L, Bruneval P, Iwawaki T, Kneilling M, Yamasaki S, Goodall J, Mallat Z.

Necrotic Cell Sensor Clec4e Promotes a Proatherogenic Macrophage Phenotype Through Activation of the Unfolded Protein Response.

Circulation 134: 1039-51. 2016

 

Nojiri H, Miyagawa K, Banno S, Sakamoto I, Koike M, Sawa M, Iwase Y, Kudo H, Sakai T, Kaneko K.

Lumbar artery branches coursing vertically over the intervertebral discs of the lower lumbar spine: an anatomic study.

Eur. Spine J. 25: 4195-98. 2016

 

Tsuboyama K, Koyama-Honda I, Sakamaki Y, Koike M, Morishita H, Mizushima N.

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane.

Science 354:1036-41. 2016

 

Yamanaka T, Tosaki A, Miyazaki H, Kurosawa M, Koike M, Uchiyama Y, Maity SN, Misawa H, Takahashi R, Shimogori T, Hattori N, Nukina N.

Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS.

Sci Rep. 6:34575. 2016

 

Honda Y, Otsuka A, Ono S, Yamamoto Y, Seidel JA, Morita S, Hirata M, Kataoka TR, Takenouchi T, Fujii K, Kanekura T, Okubo Y, Takahashi K, Yanagi T, Hoshina D, Hata H, Abe R, Fujimura T, Funakoshi T, Yoshino K, Masuzawa M, Amoh Y, Tanaka R, Fujisawa Y, Honda T, Kabashima K.

Infiltration of PD-1-positive cells in combination with tumor site PD-L1 expression is a positive prognostic factor in cutaneous angiosarcoma.

Oncoimmunology 6: e1253657. 2016

 

Shigehara Y, Okuda S, Nemer G, Chedraoui A, Hayashi R, Bitar F, Nakai H, Abbas O, Daou L, Abe R, Sleiman MB, Kibbi AG, Kurban M, Shimomura Y.

Mutations in SDR9C7 gene encoding an enzyme for vitamin A metabolism underlie autosomal recessive congenital ichthyosis.

Hum. Mol. Genet. 25: 4484-93. 2016

 

Shigehara Y, Okuda S, Nemer G, Chedraoui A, Hayashi R, Bitar F, Nakai H, Abbas O, Daou L, Abe R, Sleiman MB, Kibbi AG, Kurban M, Shimomura Y.

Mutations in SDR9C7 gene encoding an enzyme for vitamin A metabolism underlie autosomal recessive congenital ichthyosis.

Hum. Mol. Genet. Aug 18. 2016

 

Hayashi R, Abe R, Shimomura Y.

Expression studies of nectin-1 in human hair follicles and identification of a p63-responsive element in the NECTIN1 promoter.

J. Dermatol. Sci. 84: 221-4. 2016

 

Yamaguchi Y, Abe R, Haga N, Shimizu H.

A case of drug-associated dermatomyositis following ipilimumab therapy.

Eur. J. Dermatol. 26: 320-1. 2016

 

Ito T, Kohashi K, Yamada Y, Iwasaki T, Maekawa A, Kuda M, Hoshina D, Abe R, Furue M, Oda Y.

Prognostic Significance of Forkhead Box M1 (FOXM1) Expression and Antitumor Effect of FOXM1 Inhibition in Angiosarcoma.

J. Cancer. 7: 823-30. 2016

 

Hama N, Shimomura Y, Arinami H, Maruyama R, Abe R.

Localized heat urticaria: Positive reaction of preheated autologous serum skin test.

J. Dermatol. 43:1099-100. 2016

 

Shiba K, Abe R, Miyauchi T, Nomura T, Kondo T, Shimizu H.

Massive petechiae as an initial symptom of Waldenström’s macroglobulinemia.

Int. J. Dermatol. 55:e361-2. 2016

 

Tsurusaki S, Tahara-Hanaoka S, Shibagaki S, Miyake S, Imai M, Shibayama S, Kubo M, Shibuya A.

Allergin-1 inhibits TLR2-mediated mast cell activation and suppresses dermatitis.

Int. Immunol. 28:605-9. 2016

 

Udayanga KG, Nakamura Y, Nakahashi-Oda C, Shibuya A.

Immunoreceptor CD300a on mast cells and dendritic cells regulates neutrophil recruitment in a murine model of sepsis.

Int. Immunol. 28:611-5. 2016

 

Sato K, Honda SI, Shibuya A, Shibuya K.

Improved protocol for the isolation of naïve follicular dendritic cells.

Mol. Immunol. 78: 140-5. 2016

 

Kanaya M, Shibuya K, Hirochika R, Kanemoto M, Ohashi K, Okada M, Wagatsuma Y, Cho Y, Kojima H, Teshima T, Imamura M, Sakamaki H, Shibuya A.

Soluble DNAM-1, as a Predictive Biomarker for Acute Graft-Versus-Host Disease.

PLoS One 11: e0154173. 2016

 

Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ.

Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.

Immunity 45:1299-310. 2016

 

Goto Y, Uematsu S, Kiyono H.

Epithelial glycosylation in gut homeostasis and inflammation.

Nat. Immunol. 17: 1244-51. 2016

 

Imagawa Y, Saitoh T, Tsujimoto Y.

Vital staining for cell death identifies Atg9a-dependent necrosis in developmental bone formation in mouse.

Nat. Commun. 7: 13391. 2016

 

Maruyama K, Kawasaki T, Hamaguchi M, Hashimoto M, Furu M, Ito H, Fujii T, Takemura N, Karuppuchamy T, Kondo T, Kawasaki T, Fukasaka M, Misawa T, Saitoh T, Suzuki Y, Martino MM, Kumagai Y, Akira S.

Bone-protective Functions of Netrin 1 Protein.

J. Biol. Chem. 291: 23854-68. 2016

 

Santeford A, Wiley LA, Park S, Bamba S, Nakamura R, Gdoura A, Ferguson TA, Rao PK, Guan JL, Saitoh T, Akira S, Xavier R, Virgin HW 4th, Apte RS.

Impaired autophagy in macrophages promotes inflammatory eye disease.

Autophagy. 12: 1876-85. 2016

 

Isaka Y, Takabatake Y, Takahashi A, Saitoh T, Yoshimori T.

Hyperuricemia-induced inflammasome and kidney diseases.

Nephrol .Dial. Transplant. 31: 890-6. 2016

 

Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S. Pillars Article: Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product.

J. Immunol. 162: 3749-3752. 1999. J Immunol. 197: 2563-6. 2016

 

Ta HM, Le TM, Ishii H, Takarada-Iemata M, Hattori T, Hashida K, Yamamoto Y, Mori K, Takahashi R, Kitao Y, Hori O.

Atf6α deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis.

J. Neurochem. 139:1124-37. 2016

 

Tanaka M, Miyajima A.

Liver regeneration and fibrosis after inflammation.

Inflammation and Regeneration, 2016

 

Toyonaga T, Torigoe S, Motomura Y, Kamichi T, Hayashi JM, Morita YS, Noguchi N, Chuma Y, Kiyohara H, Matsuo K, Tanaka H, Nakagawa Y, Sakuma T, Ohmuraya M, Yamamoto T, Umemura M, Mastuzaki G, Yoshikai Y, Yano I, Miyamoto T, Yamasaki S.

C-type lectin receptor DCAR recognizes mycobacterial phosphatidyl-inositol mannosides to promote a Th1 response during infection.

Immunity, 45:1245-57, 2016

 

Yamaguchi H, Arakawa S*(equally contribution), Kanaseki T, Miyatsuka T, Fujitani Y, Watada H, Tsujimoto Y, Shimizu S.

Golgi membrane-associated degradation pathway in yeast and mammals.

EMBO J. 35: 1991-2007, 2016

 

Shah S, Nagata M, Yamasaki S, Williams SJ.

Total synthesis of a cyclopropane-fatty acid α-glucosyl diglyceride from Lactobacillus plantarum and identification of its ability to signal through Mincle.

Chem Commun (Camb). 52: 10902-5. 2016

 

Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, Saito T, *Yamasaki S.

Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1.

Nat. Commun. 7: 12756. 2016

 

Shibata K, Omahdi Z, Yamasaki S.

Necroptosis DAMPens anti-tumor immunity.

Cell Death Discovery, 2: 16033. 2016

 

Pastuhov SI, Fujiki K, Tsuge A, Asai K, Ishikawa S, Hirose K, Matsumoto K, Hisamoto, N.

The core molecular machinery used for engulfment of apoptotic cells regulates the JNK pathway mediating axon regeneration in Caenorhabditis elegans.

J. Neurosci. 36: 9710-21. 2016

 

Teponno RB, Tanaka C, Jie B, Tapondjou LA, Miyamoto T.

Trifasciatosides A–J, Steroidal Saponins from Sansevieria trifasciata Prain.

Chem Pharm Bull. 64: 1347-55. 2016

 

Sato S, Koike M, Funayama M, Ezaki J, Fukuda T, Ueno T, Uchiyama Y, Hattori N.

Lysosomal storage of subunit c of mitochondrial ATP synthase in brain-specific ATP13a2-deficient mice.

Am. J. Pathol. 186: 3074-82. 2016

 

Ounaissia K, Pertuit D, Mitaine-Offer AC, Miyamoto T, Tanaka C, Delemasure S, Dutartre P, Smati D, Lacaille-Dubois MA.

New pregnane and phenolic glycosides from Solenostemma argel.

Fitoterapia, 114: 98-104. 2016

 

Ichimura K, Kakuta S, Kawasaki Y, Miyaki T, Nonami T, Miyazaki N, Enomoto S, Arai S, Koike M, Murata K, Sakai T.

Morphological process of podocyte development revealed by block-face scanning electron microscopy.

J. Cell Sci.  130: 132-42. 2016

 

Hadano S, Mitsui S, Pan L, Otomo A, Kubo M, Sato K, Ono S, Onodera W, Abe K, Koike M, Uchiyama Y, Aoki M, Warabi E, Yamamoto M, Ishii T, Yanagawa T, Shang HF, Yoshii F.

Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: Cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.

Hum. Mol. Genet. 25: 3321-40. 2016

 

Thomas Jennings R, Odkhuu E, Nakashima A, Morita N, Kobayashi T, Yamai I, Tanaka M, Suganami T, Haga S, Ozaki M, Watanabe Y, Nagai Y, Takatsu K, Kikuchi-Ueda T, Ichimonji I, Ogawa Y, Takagi H, Yamazaki T, Miyake K, Akashi-Takamura S.

Inflammatory responses increase secretion of MD-1 protein.

Int Immunol. 28: 503-12. 2016

 

Sunabori T, Koike M, Asari A, Oonuki Y, Uchiyama Y.

Suppression of Ischemia-Induced Hippocampal Pyramidal Neuron Death by Hyaluronan Tetrasaccharide through Inhibition of Toll-Like Receptor 2 Signaling Pathway.

Am. J. Pathol. 186: 2143-51. 2016

 

Yamamoto-Nonaka K, Koike M, Asanuma K, Akiba-Takagi M, Trejo JA, Seki T, Hidaka T, Ichimura K, Sakai T, Tada N, Ueno T, Uchiyama Y., Tomino Y.

Cathepsin D in podocytes plays an important role in the pathogenesis of proteinuria and chronic kidney disease.

J. Am. Soc. Nephrol. 27: 2685-700. 2016

 

Itoh T.

Stem/progenitor cells in liver regeneration.

Hepatology 64: 663-8. 2016

 

Shindo R, Yamazaki S, Ohmuraya M, Araki K, Nakano H.

Short form FLICE-inhibitory protein promotes TNFalpha-induced necroptosis in fibroblasts derived from CFLARs transgenic mice.

Biochem. Biophys. Res. Commun. 480:23-8, 2016

 

Sakata K, Araki K, Nakano H, Nishina T, Komazawa-Sakon S, Murai S, Lee GE, Hashimoto D, Suzuki C, Uchiyama Y, Notohara K, Gukovskaya AS, Gukovsky I, Yamamura KI, Baba H, Ohmuraya M.

Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome.

Sci. Rep. 6:37200, 2016

 

Nasu Y, Benke A, Arakawa S, Yoshida GJ, Kawamura G, Manley S, Shimizu S, Ozawa T.

In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy.

Sci. Rep. 6:27505, 2016

 

Ando J, Palonpon AF, Sodeoka M, Fujita, K.

High-speed Raman imaging of cellular processes.

Curr. Opin. Chem. Biol. 33: 16-24, 2016 (Review)

 

Kawamura S, Sodeoka M.

Perfluoroalkylation of Unactivated Alkenes With Acid Anhydrides as the Perfluoroalkyl Source.

Angew. Chem. Int. Ed. 55:8740-3, 2016

 

Doura T, Kamiya M, Obata F, Yamaguchi Y, Hiyama TY, Matsuda T, Fukamizu A, Noda M, Miura M, Urano Y.

Detection of LacZ-Positive Cells in Living Tissue with Single-Cell Resolution.

Angew Chem Int Ed Engl. 55:9620-4, 2016

 

Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I.

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.

Nat. Commun. 7:11635, 2016

 

Matsushita N, Suzuki M, Ikebe E, Nagashima S, Inatome R, Asano K, Tanaka M, Matsushita M, Kondo E, Iha H, Yanagi S.

Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1.

Sci. Rep. 6:31266, 2016

 

Reuscher S, Fukao Y, Morimoto R, Otagaki S, Oikawa A, Isuzugawa K, Shiratake K.

Quantitative Proteomics-Based Reconstruction and Identification of Metabolic Pathways and Membrane Transport Proteins Related to Sugar Accumulation in Developing Fruits of Pear (Pyrus communis).

Plant Cell Physiol. 57:505-18, 2016

 

Hashidume T, Kato A, Tanaka T, Miyoshi S, Itoh N, Nakata R, Inoue H, Oikawa A, Nakai Y, Shimizu M, Inoue J, Sato R.

Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects.

Sci. Rep. 6:28183, 2016

 

Bunsupa S, Hanada K, Maruyama A, Aoyagi K, Komatsu K, Ueno H, Yamashita M, Sasaki R, Oikawa A, Saito K, Yamazaki M.

Molecular Evolution and Functional Characterization of a Bifunctional Decarboxylase Involved in Lycopodium Alkaloid Biosynthesis.

Plant Physiol. 171:2432-44, 2016

 

Takemura N, Uematsu S.

Isolation and Functional Analysis of Lamina Propria Dendritic Cells from the Mouse Small Intestine.

Methods Mol Biol.1422:181-8, 2016

 

Maruzuru Y, Koyanagi N, Takemura N, Uematsu S, Matsubara D, Suzuki Y, Arii J, Kato A, Kawaguchi Y.

p53 Is a Host Cell Regulator during Herpes Simplex Encephalitis.

J. Virol. 90:6738-45, 2016

 

Kikuchi S, Kanoh D, Sato S, Sakurai Y, Suzuki M, Nakamura H.

Maleimide-functionalized closo-dodecaborate albumin conjugates (MID-AC): Unique ligation at cysteine and lysine residues enables efficient boron delivery to tumor for neutron capture therapy.

J. Control. Release. 237:160-7, 2016

 

Kamimoto K, Kaneko K, Kok CY, Okada H, Miyajima A, Itoh T.

Heterogeneity and stochastic growth regulation of biliary epithelial cells dictate dynamic epithelial tissue remodeling.

Elife. 5: e15034, 2016

 

Uchida T, Sakai O, Imai H, Ueta T.

Role of Glutathione Peroxidase 4 in Corneal Endothelial Cells.

Curr Eye Res. 15:1-6, 2016

 

Hachiya R, Shiihashi T, Shirakawa I, Iwasaki Y, Matsumura Y, Oishi Y, Nakayama Y, Miyamoto Y, Manabe I, Ochi K, Tanaka M, Goda N, Sakai J, Suganami T, Ogawa Y.

The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages.

Sci Rep. 6:28845, 2016

 

Morimoto M, Lee EY, Zhang X, Inaba Y, Inoue H, Ogawa M, Shirasawa T, Yokosuka O, Miki T

Eicosapentaenoic acid ameliorates hyperglycemia in high-fat diet-sensitive diabetes mice in conjunction with restoration of hypoadiponectinemia.

Nutr Diabetes. 6:e213, 2016

 

Dodo K, Hayamizu K, Shimizu T, Sodeoka M.

Structure-activity relationship study of 3-amino-2-indolyllactam derivatives: Development of inhibitors of oxidative stress-induced necrosis.

Chem. Pharm. Bull. 64:886-98. 2016

 

Yoshida T, Tsujioka M, Honda S, Tanaka M, Shimizu S.

Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF.

Oncotarget  7: 34420-9. 2016

 

Pastuhov SI, Matsumoto K, Hisamoto N.

Endocannabinoid signaling regulates regenerative axon navigation in C. elegans via the GPCRs NPR-19 and NPR-32.

Genes Cells 21:696-705. 2016

 

Taki K, Ohmuraya M, Tanji E, Komatsu H, Hashimoto D, Semba K, Araki K, Kawaguchi Y, Baba H, Furukawa T.

GNAS(R201H) and Kras(G12D) cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm.

Oncogene 35: 2407-12. 2016

 

Mehanna S, Suzuki C, Shibata M, Sunabori T, Imanaka T, Araki K, Yamamura K, Uchiyama Y, Ohmuraya M.

Cathepsin D in pancreatic acinar cells is implicated in cathepsin B and L degradation, but not in autophagic activity.

Biochem. Biophys. Res. Commun. 469: 405-11. 2016

 

Klionsky DJ, et al. (more than 2000 authors including Nakano H, Ohmuraya M, Koike M, Saitoh T).

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Autophagy 12: 1-222. 2016

 

Hashimoto D, Arima K, Yokoyama N, Chikamoto A, Taki K, Inoue R, Kaida T, Higashi T, Nitta H, Ohmuraya M, Hirota M, Beppu T, Baba H.

Heterogeneity of KRAS Mutations in Pancreatic Ductal Adenocarcinoma.

Pancreas. 2016 Mar 10.

 

Ota E, Mikame Y, Hirai G, Nishiyama S, Sodeoka M.

Photochemical and Additive-free Coupling Reaction of α-Cumyl α-Ketoesters via Intermolecular C-H Bond Activation.

Synlett, 27: 1128-32. 2016

 

Sun X, Hirai G, Ueki M, Hirota H, Wang Q, Hongo Y, Nakamura T, Hitora Y, Takahashi H, Sodeoka M, Osada H, Hamamoto M, Yoshida M, Yashiroda Y.

Identification of Nitrogen Signaling Factors that regulate adaptive nitrogen metabolism in fission yeast.

Sci. Rep., 6: 20856. 2016

 

Egoshi S, Takaoka Y, Saito H, Nukadzuka Y, Hayashi H, Ishimaru Y, Yamakoshi H, Dodo K, Sodeoka M, Ueda M.

Dual function of coronatine as a bacterial virulence factor against plant: possible COI1-JAZ-indipendent role.

RSC Adv., 6: 19404-12. 2016

 

Suzuki Y, Tanaka Y, Nakano S, Dodo K, Yoda N, Shinohara K, Kita K, Kaneda A, Sodeoka M, Hamada Y, Nemoto T.

A Platinum-Catalyzed Friedel-Crafts-Type C–H Coupling–Allylic Amination Cascade to Synthesize 3,4-Fused Tricyclic Indoles.

Chem. Eur. J., 22: 4418-21. 2016

 

Chayama Y, Ando L, Tamura Y, Miura M, Yamaguchi Y.

Decreases in body temperature and body mass constitute pre-hibernation remodelling in the Syrian golden hamster, a facultative mammalian hibernator.

R. Soc. Open Sci. 3:160002. 2016

 

Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H.

Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor.

Cell Rep. 14: 2362-74. 2016

 

Kobayashi K, Tanaka T, Okada S, Morimoto Y, Matsumura S, Manio MC, Inoue K, Kimura K, Yagi T, Saito Y, Fushiki T, Inoue H, Matsumoto M, Nabeshima Y.

Hepatocyte β-Klotho regulates lipid homeostasis but not body weight in mice.

FASEB J. 30: 849-62. 2016

 

Inoue H.

Central insulin-mediated regulation of hepatic glucose production.

Endocr J. 63: 1-7. 2016

 

Ozaki T, Muramatsu R, Sasai M, Yamamoto M, Kubota Y, Fujinaka T, Yoshimine T, Yamashita T.

The P2X4 receptor is required for neuroprotection via ischemic preconditioning.

Sci. Rep. 6: 25893. 2016

 

Aizawa S, Okamoto T, Sugiyama Y, Kouwaki T, Ito A, Suzuki T, Ono C, Fukuhara T, Yamamoto M, Okochi M, Hiraga N, Imamura M, Chayama K, Suzuki R, Shoji I, Moriishi K, Moriya K, Koike K, Matsuura Y.

TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis.

Nat. Commun. 7: 11379. 2016

 

Okumura R, Kurakawa T, Nakano T, Kayama H, Kinoshita M, Motooka D, Gotoh K, Kimura T, Kamiyama N, Kusu T, Ueda Y, Wu H, Iijima H, Barman S, Osawa H, Matsuno H, Nishimura J, Ohba Y, Nakamura S, Iida T, Yamamoto M, Umemoto E, Sano K, Takeda K.

Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia.

Nature 532:117-21. 2016

 

Okumura T, Takeda K, Kuchiki M, Akaishi M, Taniguchi K, Adachi-Yamada T.

GATAe regulates intestinal stem cell maintenance and differentiation in Drosophila adult midgut.

Dev. Biol. 410: 24-35. 2016

 

Morales J, Hashimoto M, Williams T, Hirawake-Mogi H, Makiuchi T, Tsubouchi A, Kaga N, Taka H, Fujimura T, Mita T, Koike M, Bringaud F, Concepción J, Hashimoto T, Embley M, Nara T.

Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids.

Proc. Biol. Sci. 283(1830). 2016

 

Shibata M, Koike M, Kusumi S, Sato N, Uchiyama Y.

A specific tripeptidyl substrate for tripeptidyl peptidase activity is effectively hydrolyzed by alanyl aminopeptidase/aminopeptidase N/CD13 in the rat kidney.

Arch. Histol. Cytol. 76: 1-8. 2016

 

Sekine S, Yao A, Hattori K, Sugawara S, Naguro I, Koike M, Uchiyama Y, Takeda K, Ichijo H.

PGAM5 deficiency confers resistance against metabolic stress in mice.

E Bio.Medicine 5: 82-92. 2016

 

Yamada D, Saiki S, Furuya N, Ishikawa K, Imamichi Y, Kambe T, Fujimura T, Ueno T, Koike M, Hattori N.

Lysosomal neutralization triggered by Zn2+ accumulation through ZnT2 inhibits autophagy.

Biochem. Biophys. Res. Commun. 471: 109-16. 2016

 

Xie C, Ginet V, Sun Y, Koike M, Zhou K, Li T, Li H, Li Q, Wang X, Uchiyama Y, Truttmann, AC, Kroemer G., Puyal J, Blomgren K, Zhu C.

Neuroprotection by selective neuronal deletion of autophagy-related gene ATG7 in neonatal brain injury.

Autophagy 12: 410-23. 2016

 

Kerscher B, Dambuza IM, Christofi M, Reid DM, Yamasaki S, Willment JA, Brown GD.

Signalling through MyD88 drives surface expression of the mycobacterial receptors MCL (Clecsf8, Clec4d) and Mincle (Clec4e) following microbial stimulation.

Microbes Infect. 18: 505-9. 2016

 

Kerscher B, Wilson GJ, Reid DM, Mori D, Taylor JA, Besra GS, Yamasaki S, Willment JA, Brown GD.

Mycobacterial receptor, Clec4d (CLECSF8, MCL), is coregulated with Mincle and upregulated on mouse myeloid cells following microbial challenge.

Eur. J. Immunol. 46: 381-9. 2016

 

Avunduk S, Mitaine-Offer AC, Miyamoto T, Tanaka C, Lacaille-Dubois MA.

Cycloartane-Type Saponins from Astragalus tmoleus var. tmoleus.

Nat. Prod. Commun. 11: 37-8. 2016

 

Rezgui A, Mitaine-Offer AC, Miyamoto T, Tanaka C, Delemasure S, Dutartre P, Lacaille-Dubois MA.

Oleanolic acid and hederagenin glycosides from Weigela stelzneri.

Phytochemistry 123: 40-7. 2016

 

Haraguchi N, Kikuchi N, Morishima Y, Matsuyama M, Sakurai H, Shibuya A, Shibuya K, Taniguchi M, Ishii Y.

Activation of murine invariant NKT cells promotes susceptibility to candidiasis by IL-10-induced modulation of phagocyte antifungal activity.

Eur. J. Immunol. 46: 1691-703. 2016

 

Honda S, Sato K, Totsuka N, Fujiyama S, Fujimoto M, Miyake K, Nakahashi-Oda C, Tahara-Hanaoka S, Shibuya K, Shibuya A.

Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling.

Nat. Commun. 7: 11498. 2016

 

Iguchi-Manaka A, Okumura G, Kojima H, Cho Y, Hirochika R, Bando H, Sato T, Yoshikawa H, Hara H, Shibuya A, Shibuya K.

Increased soluble CD155 in the serum of cancer patients.

PLoS ONE 11: e0152982. 2016

 

Nakahashi-Oda C, Udayanga KGS, Nakamura Y, Nakazawa Y, Miki H, Iino S, Tahara-Hanaoka S, Shibuya K, Shibuya A.

Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces.

Nat. Immunol. 17: 441-50. 2016

 

Georgiev H, Ravens I, Shibuya A, F.ANvrster R, Bernhardt G.

CD155/CD226-interaction impacts on the generation of innate CD8+ thymocytes by regulating iNKT-cell differentiation.

Eur. J. Immunol. 46: 993-1003. 2016

 

Vo.A.V, Takenaka E, Shibuya A, Shibuya K.

Expression of DNAM-1 (CD226) on inflammatory monocytes.

Mol. Immunol, 69: 70-6. 2016

 

Maruzuru Y, Koyanagi N, Takemura N, Uematsu S, Matsubara D, Suzuki Y, Arii J, Kato A, Kawaguchi Y.

p53 is a Host Cell Regulator during Herpes Simplex Encephalitis.

J. Virol. 2016 May 11. [Epub ahead of print]

 

Tanimizu N, Kaneko K, Itoh T, Ichinohe N, Ishii M, Mizuguchi T, Hirata K, Miyajima A, Mitaka T.

Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement.

Hepatology 2016 Feb 29. [Epub ahead of print]

 

Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, Takano Y, Hikasa H, Itoh T, Suzuki SO, Kurihara H, Aishima S, Leask A, Sasaki T, Nakano T, Nishina H, Nishikawa Y, Sekido Y, Nakao K, Shin-Ya K, Mimori K, Suzuki A.

Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.

Proc. Natl. Acad. Sci. U A. 113: E71-80. 2016

 

Watanabe Y, Nagai Y, Honda H, Okamoto N, Yamamoto S, Hamashima T, Ishii Y, Tanaka M, Suganami T, Sasahara M, Miyake K, Takatsu K.

Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice.

Sci. Rep. 6: 23097. 2016

 

Alam T, Maruyama H, Li C, Pastuhov SI, Nix P, Bastiani M, Hisamoto N, Matsumoto K.

Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans.

Nat. Commun. 7: 10388. 2016

 

Fukuzono T, Pastuhov SI, Fukushima O, Li C, Hattori A, Iemura S, Natsume T, Shibuya H, Hanafusa H, Matsumoto K, Hisamoto, N.

The chaperone complex BAG2–HSC70 regulates localization of C. elegans Leucine-rich repeat kinase LRK-1 in the Golgi.

Genes to Cells 21: 311-24, 2016

 

Saitoh T, Akira S.

Regulation of the Inflammasomes by Autophagy.

Allergy Clin. Immunol. 138: 28-36. 2016

 

Park S, Buck MD, Desai C, Zhang X, Loginicheva E, Martinez J, Freeman ML, Saitoh T, Akira S, Guan JL, He YW, Blackman MA, Handley SA, Levine B, Green DR, Reese TA, Artyomov MN, Virgin HW.

Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation.

Cell Host Microbe 19:91-101. 2016

 

Okubo H, Kushiyama A, Sakoda H, Nakatsu Y, Iizuka M, Taki N, Fujishiro M, Fukushima T, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Asahara T, Yoshida Y, Chonan O, Encinas J, Asano T.

Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice.

Sci. Rep. 6: 20157. 2016

 

Otaki Y, Takahashi H, Watanabe T, Funayama A, Netsu S, Honda Y, Narumi T, Kadowaki S, Hasegawa H, Honda S, Arimoto T, Shishido T, Miyamoto T, Kamata H, Nakajima O, Kubota I.

HECT-Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin-Interacting Protein and Ameliorates Reactive Oxygen Species-Induced Cardiotoxicity.

J. Am. Heart Assoc. 5(1). 2016

 

Miyake M, Ito Y, Sawada M, Sakai K, Suzuki H, Sakamoto T, Sawamoto K, Kamijima M.

Subchronic inhalation exposure to 2-ethyl-1-hexanol impairs the mouse olfactory bulb via injury and subsequent repair of the nasal olfactory epithelium.

Arch Toxicol. 2016 Apr 8 [Epub ahead of print]

 

Ogino T, Sawada M, Takase H, Nakai C, Herranz-Pérez V, Cebrián-Silla A, Kaneko N, Manuel García-Verdugo J, Sawamoto K.

Characterization of multiciliated ependymal cells that emerge in the neurogenic niche of the aged zebrafish brain.

J. Comp. Neurol. 2016 Mar 16. [Epub ahead of print]

 

Hirota Y, Sawada M, Huang SH, Ogino T, Ohata S, Kubo A, Sawamoto K.

Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular-Subventricular Zone.

Neurochem. Res. 41: 222-30. 2016

 

Le TM, Hashida K, Ta HM, Takarada-Iemata M, Kokame K, Kitao Y, Hori O.

Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson’s Disease.

Parkinsons Dis. 2016;2016:6163934.

 

Kezuka D, Takarada-Iemata M, Hattori T, Mori K, Takahashi R, Kitao Y, Hori O.

Deletion of Atf6α enhances kainate-induced neuronal death in mice.

Neurochem. Int. 92: 67-74. 2016

 

Maekawa M, Honoki R, Ihara Y, Sato R, Oikawa A, Kanno Y, Ohta H, Seo M, Saito K, Masuda S.

Impact of the plastidial stringent response in plant growth and stress responses.

Nat Plants. 1:15167, 2015

 

Kusuda H, Koga W, Kusano M, Oikawa A, Saito K, Hirai MY, Yoshida KT.

Ectopic expression of myo-inositol 3-phosphate synthase induces a wide range of metabolic changes and confers salt tolerance in rice.

Plant Sci. 232:49-56, 2015

 

Zargar SM, Kurata R, Inaba S, Oikawa A, Fukui R, Ogata Y, Agrawal GK, Rakwal R, Fukao Y.

Quantitative proteomics of Arabidopsis shoot microsomal proteins reveals a cross-talk between excess zinc and iron deficiency.

Proteomics. 15:1196-201, 2015

 

Oikawa A, Otsuka T, Nakabayashi R, Jikumaru Y, Isuzugawa K, Murayama H, Saito K, Shiratake K.

Metabolic Profiling of Developing Pear Fruits Reveals Dynamic Variation in Primary and Secondary Metabolites, Including Plant Hormones.

PLoS One 10:e0131408, 2015

 

Kinoshita T, Imamura R, Kushiyama H, Suda T.

NLRP3 mediates NF-κB activation and cytokine induction in microbially induced and sterile inflammation.

PLoS One 10:e0119179. 2015

 

Tsuchiya Y, Nakabayashi O, Nakano H.

FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP.

Int. J. Mol. Sci. 16: 30321-41. 2015

 

Sakata K, Hashimoto D, Taki K, Nakahara O, Ohmuraya M, Chikamoto A, Beppu T, Baba H.

Successful surgical internal drainage of postoperative pancreatic pseudocyst through pancreaticojejunostomy with distal pancreatectomy: a case report.

Surg. Case Rep. 1: 54. 2015

 

Nakano H, Piao X, Shindo R, Komazawa-Sakon S.

Cellular FLICE-Inhibitory Protein Regulates Tissue Homeostasis.

Curr. Top Microbiol. Immunol. 2015 Jul 10.

 

Nakagawa Y, Sakuma T, Sakamoto T, Ohmuraya M, Nakagata N, Yamamoto T.

Production of knockout mice by DNA microinjection of various CRISPR/Cas9 vectors into freeze-thawed fertilized oocytes.

BMC Biotechnol. 15: 33. 2015

 

Ida S, Ozaki N, Araki K, Hirashima K, Zaitsu Y, Taki K, Sakamoto Y, Miyamoto Y, Oki E, Morita M, Watanabe M, Maehara Y, Yamamura K, Baba H, Ohmuraya M.

SPINK1 Status in Colorectal Cancer, Impact on Proliferation, and Role in Colitis-Associated Cancer.

Mol. Cancer Res. 13: 1130-8. 2015

 

Hashimoto D, Chikamoto A, Sakata K, Nakagawa S, Hayashi H, Ohmuraya M, Hirota M, Yoshida N, Beppu T, Baba H.

Staging laparoscopy leads to rapid induction of chemotherapy for unresectable pancreatobiliary cancers.

Asian J. Endosc. Surg. 8: 59-62. 2015

 

Hashimoto D, Chikamoto A, Ohmuraya M, Abe S, Nakagawa S, Beppu T, Takamori H, Hirota M, Baba H.

Impact of Postoperative Weight Loss on Survival After Resection for Pancreatic Cancer.

JPEN J. Parenter Enteral Nutr. 39:598-603. 2015

 

Chiu L, Palonpon AF, Smith NI, Kawata S, Sodeoka M, Fujita K.

Dual-Polarization Raman Spectral Imaging to Extract Overlapping Molecular Fingerprints of Living Cells.

J. Biophotonics, 8: 546-54. 2015

 

Okazaki M, Kurabayashi K, Asanuma M, Saito Y, Dodo K, Sodeoka M.

VDAC3 gating is activated by suppression of disulfide-bond formation between the N-terminal region and the bottom of the pore.

Biochim. Biophys. Acta, 1848: 3188-96. 2015

 

Hayamizu K, Terayama N, Hashizume D, Dodo K, Sodeoka M. Unique features of chiral palladium enolates derived from β-ketoamide: Structure and catalytic asymmetric Michael and fluorination reactions.

Tetrahedron 71: 6594-601. 2015

 

Ota E, Mikame Y, Hirai G, Koshino H, Nishiyama S, Sodeoka M.

Photo-induced formation of cyclopropanols from α-ketoamides via γ-C-H bond activation.

Tetrahedron Lett. 56:5991-94. 2015

 

Cui J, Matsuoka S, Kinoshita M, Matsumori N, Sato F, Murata M, Ando J, Yamakoshi H, Dodo K, Sodeoka M.

Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior.

Bioorg. Med. Chem. 23: 2989-94. 2015

 

Egami H, Usui Y, Kawamura S, Shimizu R, Nagashima S, Sodeoka M.

Mechanistic Study on A unique SN2’-type reaction of allylic alcohols with organolithium reagent accelerated by a proximal trifluoromethyl group.

J. Fluor. Chem., 179: 121-8. 2015

 

Hirai G, Nishizawa E, Kakumoto D, Morita M, Okada M, Hashizume D, Nagashima S, Sodeoka M.

Reactions of Carbonyl Compounds with Phosphorus Ylide Generated from Tribromofluoromethane and Tris(dimethylamino)phosphine.

Chem. Lett. 44: 1389-91. 2015

 

Egami H, Usui Y, Kawamura S, Nagashima S, Sodeoka M.

Product Control in Alkene Trifluoromethylation: Hydro-trifluoromethylation, Vinylic Trifluoromethylation, and Iodo-trifluoromethylation Using Togni Reagent.

Chem. Asian J. 10: 2190-9. 2015

 

Kawamura S, Egami H, Sodeoka M.

Aminotrifluoromethylation of Olefins via Cyclic Amine Formation: Its Mechanistic Study and Application to Synthesis of Trifluoromethylated Pyrrolidines.

J. Am. Chem. Soc. 137: 4865-73. 2015

 

Ando J, Kinoshita M, Cui J, Yamakoshi H, Dodo K, Fujita K, Murata M, Sodeoka M.

Sphingomyelin distribution in lipid rafts of artificial monolayer membranes visualized by Raman microscopy.

Proc. Nat. Acad. Sci.USA. 112: 4558-63. 2015

 

Misawa T, Dodo K, Ishikawa M, Hashimoto Y, Sagawa M, Kizaki M, Aoyama H.

Structure–activity relationships of benzhydrol derivatives based on 10-acetoxychavicol acetate (ACA) and their inhibitory activities on multiple myeloma cell growth via inactivation of the NF-kappaB pathway.

Bioorg. Med. Chem. 23: 2241-6. 2015

 

Lu S, Nishimura S, Hirai G, Ito M, Kawahara T, Izumikawa M, Sodeoka M, Shin-ya K, Tsuchida T, Kakeya H.

Saccharothriolides A-C, Novel Phenyl-substituted 10-Membered Macrolides from a Rare Actinomycete Saccharothrix sp.

Chem. Commun. 51: 8074-7. 2015

 

Hirai G, Sodeoka M.

Focused Library with Core Structure Extracted from Natural Products and Modified: Application to Phosphatase Inhibitors and Several Biochemical Findings.

Acc. Chem. Res. 48: 1464-73. 2015

 

Arakawa S, Nakanomyo I, Kudo-Sakamoto Y, Akazawa H, Komuro I, Shimizu S.

Identification of a novel compound that inhibits both mitochondria-mediated necrosis and apoptosis.

Biochem. Biophys. Res. Commun. 467: 1006-11. 2015

 

Yamaguchi Y, Miura M.

Programmed Cell Death and Caspase Functions During Neural Development.

Curr. Top Dev. Biol. 114: 159-84. 2015

 

Yamaguchi Y, Miura M.

Programmed cell death in neurodevelopment.

Dev. Cell 32:478-90. 2015

 

Sato S, Nakamura K, Nakamura H.

Tyrosine-Specific Chemical Modification with in situ Hemin-Activated Luminol Derivatives.

ACS Chem. Biol. 10: 2633-40. 2015

 

Li G, Azuma S, Sato S, Minegishi H, Nakamura H.

ortho-Carboranylphenoxyacetanilides as Inhibitors of Hypoxia-Inducible Factor (HIF)-1Transcriptional Activity and Heat Shock Protein (HSP) 60 Chaperon Activity.

Bioorg. Med. Chem. Lett. 25: 2624-8. 2015

 

Sato S, Morita K, Nakamura H.

Regulation of target protein knockdown and labeling using ligand-directed Ru(bpy)3 photocatalyst.

Bioconjugate Chem. 26: 250-6. 2015

 

Asahara S, Etoh H, Inoue H, Teruyama K, Shibutani Y, Ihara Y, Kawada Y, Bartolome A, Hashimoto N, Matsuda T, Koyanagi-Kimura M, Kanno A, Hirota Y, Hosooka T, Nagashima K, Nishimura W, Inoue H, Matsumoto M, Higgins MJ, Yasuda K, Inagaki N, Seino S, Kasuga M, Kido Y.

Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c.

Proc. Natl. Acad .Sci. USA. 112: 8332-7. 2015

 

Matsuda T, Takahashi H, Mieda Y, Shimizu S, Kawamoto T, Matsuura Y, Takai T, Suzuki E, Kanno A, Koyanagi-Kimura M, Asahara S, Bartolome A, Yokoi N, Inoue H, Ogawa W, Seino S, Kido Y.

Regulation of Pancreatic β Cell Mass by Cross-Interaction between CCAAT Enhancer Binding Protein β Induced by Endoplasmic Reticulum Stress and AMP-Activated Protein Kinase Activity.

PLoS One 10: e0130757. 2015

 

Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y, Matsumoto M, Yamamoto Y, Harada K, Kaneko S, Oyadomari S, Ozaki M, Kasuga M, Inoue H.

Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice.

Hepatology 61:1343-56. 2015

 

Chalabi-Dchar M, Cassant-Sourdy S, Duluc C, Fanjul M, Lulka H, Samain R, Roche C, Breibach F, Delisle MB, Poupot M, Dufresne M, Shimaoka T, Yonehara S, Mathonnet M, Pyronnet S, Bousquet C.

Loss of Somatostatin Receptor Subtype 2 Promotes Growth of KRAS-Induced Pancreatic Tumors in Mice by Activating PI3K Signaling and Overexpression of CXCL16.

Gastroenterology 148:1452-65. 2015

 

Lee Y, Sasai M, Ma JS, Sakaguchi N, Ohshima J, Bando H, Saitoh T, Akira S, Yamamoto M. p62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen.

Cell Rep. 13:223-33. 2015

 

Ohshima J, Sasai M, Liu J, Yamashita K, Ma JS, Lee Y, Bando H, Howard JC, Ebisu S, Hayashi M, Takeda K, Standley DM, Frickel EM, Yamamoto M.

RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.

Proc. Natl. Acad. Sci. USA. 112: E4581-90, 2015

 

Ito D, Nojima S, Nishide M, Okuno T, Takamatsu H, Kang S, Kimura T, Yoshida Y, Morimoto K, Maeda Y, Hosokawa T, Toyofuku T, Ohshima J, Kamimura D, Yamamoto M, Murakami M, Morii E, Rakugi H, Isaka Y, Kumanogoh A.

mTOR Complex Signaling through the SEMA4A-Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells

.J. Immunol. 195: 934-43. 2015

 

Man SM, Karki R, Malireddi RK, Neale G, Vogel P, Yamamoto M, Lamkanfi M, Kanneganti TD. The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.

Nat. Immunol. 16: 467-75. 2015

 

Okumura T, Sasamura T, Inatomi M, Hozumi S, Nakamura M, Hatori R, Taniguchi K, Nakazawa N, Suzuki E, Maeda R, Yamakawa T, Matsuno K.

Class I myosins have overlapping and specialized functions in left-right asymmetric development in Drosophila.

Genetics 199: 1183-99. 2015

 

Sakai O, Uchida T, Roggia MF, Imai H, Ueta T, Amano S.

Role of Glutathione Peroxidase 4 in Glutamate-induced Oxytosis in the Retina.

PLoS One 10: e0130467. 2015

 

Kumagai T, Kozakai Y, Ishino T, Yajima Y, Nakagawa Y, Imai H.

Nrf2 up-regulates the induction of acidic sphingomyelinase by electrophiles.

J. Biochem. 158:127-37. 2015

 

Mori J, Tang H, Kawabata A, Koike M, Mori Y.

Human herpesvirus 6A U14 is important for virus maturation.

J. Virol. 90: 1677-81. 2015

 

Fuse A, Furuya N, Kakuta S, Inose A, Sato M, Koike M, Saiki S, Hattori N.

VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process.

FEBS lett. 589: 1430-6. 2015

 

Rinchai D, Riyapa D, Buddhisa S, Utispan K, Titball RW, Stevens PM, Stevens JM, Ogawa M, Tanida I, Koike M, Uchiyama, Y., Ato, M., Lertmemongkolchai, G.

Macroautophagy is essential for killing of Burkholderia pseudomallei in human neutrophils.

Autophagy 11: 748-55. 2015

 

Nanao, T, Koike M, Yamaguchi J, Sasaki M, Uchiyama, Y.

Cellular localization and tissue distribution of endogenous DFCP1 protein.

Biomed. Res. 36: 121-33. 2015

 

Uemura N, Koike M, Asai K, Kinoshita M, Fujiwara-Ishikawa T, Matsui H, Naruse K, Sakamoto N, Uchiyama Y, Todo T, Takeda SI, Yamakado H, Takahashi R.

Viable neuronopathic Gaucher disease model in medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein.

Plos Genet. 11: e1005065. 2015.

 

Ichimura K, Miyazaki N, Sadayama S, Murata K, Koike M, Nakamura K, Ohta K, Sakai T.

Three-dimensional architecture of podocytes revealed by block-face scanning electron microscopy.

Sci. Rep. 5: 8993. 2015

 

Nori S, Okada Y, Nishimura S, Sasaki T, Itakura G, Kobayashi Y, Renault-Mihara F, Shimizu A, Koya I, Yoshida R, Kudoh J, Koike M, Uchiyama Y, Ikeda, E, Toyama Y, Nakamura M, Okano, H.

Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition. Stem.

Cell Rep. 4: 360-73. 2015

 

Asano, T, Koike M, Sakata S, Takeda Y, Nakagawa T, Hatano T, Ohashi S, Funayama M, Yoshimi K, Asanuma M, Toyokuni S, Mochizuki S, Uchiyama Y, Hattori N, Iwai K.

Possible involvement of iron-induced oxidative insults in neurodegeneration.

Neurosci. Lett. 588: 29-35. 2015.

 

Ueno Y, Koike M, Shimada Y, Shimura H, Uchiyama Y, Hattori N, Urabe T.

L-carnitine enhances axonal plasticity and improves white-matter lesions after chronic hypoperfusion in rat brain.

J. Cereb. Blood Flow Metab. 35: 382-91. 2015

 

Tanaka M, Nishitai G.

Immune Regulation by Dead Cell Clearance.

Curr. Top Microbiol. Immunol. 2015, Aug 18.

 

Motomura Y, Kanno S, Asano K, Tanaka M, Hasegawa Y, Katagiri H, Saito T, Hara H, Nishio H, Hara T, Yamasaki S.

Identification of Pathogenic Cardiac CD11c+ Macrophages in Nod1-Mediated Acute Coronary Arteritis.

Arterioscler Thromb Vasc Biol. 35: 1423-33. 2015

 

Inoue H, Matsuzaki Y, Tanaka A, Hosoi K, Ichimura K, Arasaki K, Wakana Y, Asano K, Tanaka M, Okuzaki D, Yamamoto A, Tani K, Tagaya M.

gamma-SNAP stimulates disassembly of endosomal SNARE complexes and regulates endocytic trafficking pathways.

Cell Sci. 128: 2781-94. 2015

 

Asano K, Takahashi N, Ushiki M, Monya M, Aihara F, Kuboki E, Moriyama S, Iida M, Kitamura H, Qiu CH, Watanabe T, Tanaka M.

Intestinal CD169(+) macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes.

Nat. Commun.6: 7802. 2015

 

Kido T, Koui Y, Suzuki K, Kobayashi A, Miura Y, Chen EY, Tanaka M, Miyajima A.

CPM is a useful cell surface marker to isolate expandable bi-potential liver progenitor cells derived from human iPS cells.

Stem Cell Reports. 5:508-515 (2015)

 

Komori T, Tanaka M, Furuta H, Akamizu T, Miyajima A, Morikawa Y.

Oncostatin M is a potential agent for the treatment of obesity and related metabolic disorders: a study in mice.

Diabetologia. 58:1868-76. 2015

 

Guo S, Li ZZ, Gong J, Xiang M, Zhang P, Zhao GN, Li M, Zheng A, Zhu X, Lei H, Tanaka M, Li H.

Oncostatin M Confers Neuroprotection against Ischemic Stroke.

J. Neurosci. 35: 12047-62. 2015

 

Kurihara T, Arimochi H, Bhuyan ZA, Ishifune C, Tsumura H, Ito M, Ito Y, Kitamura A, Maekawa Y, Yasutomo K.

CD98 Heavy Chain Is a Potent Positive Regulator of CD4+ T Cell Proliferation and Interferon-γ Production In Vivo.

PLoS One 10: e0139692. 2015

 

Oh SJ, Ahn S, Jin YH, Ishifune C, Kim JH, Yasutomo K, Chung DH.

Notch 1 and Notch 2 synergistically regulate the differentiation and function of invariant NKT cells.

J. Leukoc. Biol. 98:781-9. 2015

 

Richardson MB, Torigoe S, Yamasaki S, Williams SJ.

Mycobacterium tuberculosis β-gentiobiosyl diacylglycerides signal through the pattern recognition receptor Mincle: total synthesis and structure activity relationships.

Chem. Commun. (Camb). 51: 15027-30. 2015

 

Kiyotake R, Oh-Hora M, Ishikawa E, Miyamoto T, Ishibashi T, Yamasaki S.

Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses.

J. Biol. Chem. 290: 25322-32. 2015

 

Miyake Y, Masatsugu OH, Yamasaki S.

C-Type Lectin Receptor MCL Facilitates Mincle Expression and Signaling through Complex Formation.

J. Immunol. 194:5366-74. 2015

 

van der Peet PL, Gunawan C, Torigoe S, Yamasaki S, Williams SJ.

Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle.

Chem. Commun. (Camb). 51: 5100-3. 2015

 

Nakamura Y, Sato K, Yamamoto H, Matsumura K, Matsumoto I, Nomura T, Miyasaka T, Ishii K, Kanno E, Tachi M, Yamasaki S, Saijo S, Iwakura Y, Kawakami K.

Dectin-2 deficiency promotes Th2 response and mucin production in the lungs after pulmonary infection with Cryptococcus neoformans.

Infect. Immun. 83: 671-81. 2015

 

Behler F, Maus R, Bohling J, Knippenberg S, Kirchhof G, Nagata M, Jonigk D, Izykowski N, Mägel L, Welte T, Yamasaki S, Maus UA.

Macrophage-inducible C-type lectin Mincle-expressing dendritic cells contribute to control of splenic Mycobacterium bovis BCG infection in mice.

Infect. Immun. 83: 184-96. 2015

 

Phongsisay V, Iizasa E, Hara H, Yamasaki S.

3-O-sulfo-β-D-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5.

Mol. Immunol. 63: 595-9. 2015

 

Konoki K, Okada K, Kohama M, Matsuura H, Saito K, Cho Y, Nishitani G, MiyamotoT, Fukuzawa S, Tachibana K, Yotsu-Yamashita M.

Identification of okadaic acid binding protein 2 in reconstituted sponge cell clusters from Halichondria okadai and its contribution to the detoxification of okadaic acid.

Toxicon. 108: 38-45. 2015

 

Pertuit D, Mitaine-Offer AC, Miyamoto T, Tanaka C, Delemasure S, Dutartre P, Lacaille-Dubois MA.

A New Aromatic Compound from the Stem Bark of Terminaliacatappa.

Nat. Prod. Commun. 10: 1005-7. 2015

 

Rezgui A, Mitaine-Offer AC, Miyamoto T, Tanaka C, Lacaille-Dubois MA.

Spirostane-type saponins from Dracaena fragrans “Yellow Coast”.

Nat. Prod. Commun. 10:37-8. 2015

 

Aslan Erdem S, Mitaine-Offer AC, Miyamoto T, Kartal M, Lacaille-Dubois MA.

Triterpene saponins from Eryngium kotschyi.

Phytochemistry 110:160-5. 2015

 

Abe R.

Immunological response in Stevens-Johnson syndrome and toxic epidermal necrolysis.

J. Dermatol. 42: 42-8. 2015

 

Suda G, Yamamoto Y, Nagasaka A, Furuya K, Kudo M, Chuganji Y, Tsukuda Y, Tsunematsu S, Sato F, Terasita K, Nakai M, Horimoto H, Sho T, Natsuizaka M, Ogawa K, Ohnishi S, Chuma M, Fujita Y, Abe R, Taniguchi M, Nakagawa M, Asahina Y, Sakamoto N; NORTE Study Group.

Serum granulysin levels as a predictor of serious telaprevir-induced dermatological reactions.

Hepatol. Res. 45: 837-45. 2015

 

Aihara M, Kano Y, Fujita H, Kambara T, Matsukura S, Katayama I, Azukizawa H, Miyachi Y, Endo Y, Asada H, Miyagawa F, Morita E, Kaneko S, Abe R, Ochiai T, Sueki H, Watanabe H, Nagao K, Aoyama Y, Sayama K, Hashimoto K, Shiohara T; SJS/TEN Study Group.

Efficacy of additional i.v. immunoglobulin to steroid therapy in Stevens-Johnson syndrome and toxic epidermal necrolysis.

J. Dermatol. 42: 768-77. 2015

 

Kanemaru K, Noguchi E, Tokunaga T, Nagai K, Hiroyama T, Nakamura Y, Tahara-Hanaoka S, Shibuya A.

Tie2 Signaling Enhances Mast Cell Progenitor Adhesion to Vascular Cell Adhesion Molecule-1 (VCAM-1) through α4β1 Integrin.

PLoS One 10: e0144436. 2015

 

Weinstein JR, Quan Y, Hanson JF, Colonna L, Iorga M, Honda S, Shibuya K, Shibuya A, Elkon KB, M.ANvller T. IgM-Dependent Phagocytosis in Microglia Is Mediated by Complement Receptor 3, Not Fc.FNa/Nl Receptor.

J. Immunol. 195: 5309-17. 2015

 

Shibuya A, Honda S.

Immune regulation by Fcα/μ receptor (CD351) on marginal zone B cells and follicular dendritic cells.

Immunol Rev. 268: 288-95. 2015

 

Niizuma K, Tahara-Hanaoka S, Noguchi E, Shibuya A.

Identification and Characterization of CD300H, a New Member of the Human CD300 Immunoreceptor Family.

J. Biol. Chem. 290: 22298-308. 2015

 

Yamashita-Kanemaru Y, Takahashi Y, Wang Y, Tahara-Hanaoka S, Honda S, Bernhardt G, Shibuya A, Shibuya K.

CD155 (PVR/Necl5) Mediates a Costimulatory Signal in CD4+ T Cells and Regulates Allergic Inflammation.

J. Immunol. 194: 5644-53. 2015

 

Miki H, Nakahashi-Oda C, Sumida T, Shibuya A.

Involvement of CD300a Phosphatidylserine Immunoreceptor in Aluminum Salt Adjuvant-Induced Th2 Responses.

J. Immunol. 194: 5069-76. 2015

 

Takeshima K, Sato K, Nabekura T, Nagamune K, Hamada H, Yoshikawa H, Shibuya A, Shibuya K.

Increased CD11b+ Gr-1+ cell population in the placenta after infection with Toxoplasma gondii.

Microbiol Immunol. 59: 95-82015

 

Kurita N, Honda S, Shibuya A.

Increased serum IgA in Fcα/μR-deficient mice on the (129 x C57BL/6) F1 genetic background.

Mo. Immunol. 63: 367-72. 2015

 

Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, Hirata M, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C.

Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis.

J. Biol. Chem. 290:29781-93. 2015

 

Matsuda H, Hosono K, Tsuru S, Kurashige C, Sekiguchi K, Akira S, Uematsu S, Okamoto H, Majima M.

Roles of mPGES-1, an inducible prostaglandin E synthase, in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model.

Life Sci. 142: 1-7. 2015

 

Flores-Langarica A, Bobat S, Marshall JL, Yam-Puc JC, Cook CN, Serre K, Kingsley RA, Flores-Romo L, Uematsu S, Akira S, Henderson IR, Toellner KM, Cunningham AF.

Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokineproduction.

Eur. J. Immunol. 45:2299-311. 2015

 

Maruyama K, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, Martino M, Akira S.

5-azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival.

J. Biol. Chem. J. Biol. Chem. 290: 9377-862015

 

Atif SM, Lee SJ, Li LX, Uematsu S, Akira S, Gorjestani S, Lin X, Schweighoffer E, Tybulewicz VL, McSorley SJ.

Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9.

Eur. J. Immunol. 45: 513-24. 2015

 

Kok CY, Miyajima A, Itoh T.

Adaptive remodeling of the biliary tree: the essence of liver progenitor cell expansion.

J. Hepatobiliary Pancreat. Sci. 22: 546-50. 2015

 

Kaneko K, Kamimoto K, Miyajima A, Itoh T.

Adaptive remodeling of the biliary architecture underlies liver homeostasis.

Hepatology 61: 2056-66. 2015

 

Ehara T, Kamei Y, Yuan X, Takahashi M, Kanai S, Tamura E, Tsujimoto K, Tamiya T, Nakagawa Y, Shimano H, Takai-Igarashi T, Hatada I, Suganami T, Hashimoto K, Ogawa Y.

Ligand-activated PPARα-dependent DNA demethylation regulates the fatty acid β-oxidation genes in the postnatal liver.

Diabetes 64: 775-84. 2015

 

Takagi M, Uno H, Nishi R, Sugimoto M, Hasegwa S, Piao J, Ihara N, Kanai S, Kakei S, Tamura Y, Suganami T, Kamei Y, Shimizu T, Yasuda A, Ogawa Y, Mizutani S.

ATM regulates adipocyte differentiation and contributes to glucose homeostasis.

Cell Reports 10: 957-67. 2015

 

Kobayashi S, Fukuhara A, Otsuki M, Suganami T, Ogawa Y, Morii E, Shimomura I.

Favine/CCDC3 is involved in lipid accumulation.

J. Biol. Chem. 290: 7443-51. 2015

 

Konuma K, Itoh M, Suganami T, Kanai S, Nakagawa N, Sakai T, Kawano H, Hara M, Kojima S, Izumi Y, Ogawa Y.

Eicosapentaenoic acid ameliorates non-alcoholic steatohepatitis in a novel mouse model using melanocortin 4 receptor-deficient mice.

PLoS One 10: e0121528. 2015

 

Murakami M, Yoshimoto T, Nakabayashi K, Tsuchiya K, Minami I, Bouchi R, Izumiyama H, Fujii Y, Abe K, Tayama C, Hashimoto K, Suganami T, Hata K, Kihara K, Ogawa Y.

Integration of transcriptome and methylome analysis of aldosterone-producing adenomas.

Eur. J. Endocrinol. 173: 185-95. 2015

 

Ogawa Y, Suganami T, Tanaka M, M. Itoh.

Parenchymal-stromal cell interaction in metabolic diseases.

Inflamm. Regen. 35: 167-71. 2015 (review)

 

Muramatsu-Kato K, *Itoh H, Kohmura-Kobayashi Y, Ferdous UJ, Tamura N, Yaguchi C, Uchida T, Suzuki K, Hashimoto K, Suganami T, Ogawa Y, Kanayama N.

Undernourishment in utero Primes Hepatic Steatosis in Adult Mice Offspring on an Obesogenic Diet; Involvement of Endoplasmic Reticulum Stress.

Sci Rep. 5: 16867. 2015

 

Li C, Hisamoto, N, Matsumoto K.

Axon regeneration is regulated by Ets–C/EBP transcription complexes generated by activation of the cAMP/Ca2+–p38 MAPK signaling pathways.

PLoS Genetics 11: e1005603. 2015

 

Pastuhov SI, Hisamoto, N, Matsumoto K.

MAP kinase cascades regulating axon regeneration in C. elegans.

Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci. 91: 63-75. 2015

 

Shibutani ST, Saitoh T, Nowag H, Münz C, Yoshimori T.

Autophagy and autophagy-related proteins in the immune system.

Nat. Immunol. 16: 1014-24. 2015

 

Kojima T, Yamada T, Akaishi R, Furuta I, Saitoh T, Nakabayashi K, Nakayama KI, Nakayama K, Akira S, Minakami H.

Role of the Atg9a gene in intrauterine growth and survival of fetal mice.

Reprod. Biol. 15: 131-8. 2015

 

Misawa T, Saitoh T, Kozaki T, Park S, Takahama M, Akira S.

Resveratrol inhibits the acetylated α-tubulin-mediated assembly of the NLRP3-inflammasome.

Int. Immunol. 27: 425-34. 2015

 

Kozaki T, Takahama M, Misawa T, Matsuura Y, Akira S, Saitoh T.

Role of zinc-finger anti-viral protein in host defense against Sindbis virus.

Int. Immunol. 27: 357-64. 2015

 

Kumar S, Ingle H, Mishra S, Mahla RS, Kumar A, Kawai T, Akira S, Takaoka A, Raut AA, Kumar H.

IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity.

Cell Death Dis. 6: e1758. 2015

 

Matsuda T, Murao N, Katano Y, Juliandi B, Kohyama J, Akira S, Kawai T, Nakashima K.

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.

Nat. Commun. 6: 6514. 2015

 

Kitai Y, Takeuchi O, Kawasaki T, Ori D, Sueyoshi T, Murase M, Akira S, Kawai T.

Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B.

J. Biol. Chem. 290:1269-80. 2015

 

Nakatsu Y, Iwashita M, Sakoda H, Ono H, Nagata K, Matsunaga Y, Fukushima T, Fujishiro M, Kushiyama A, Kamata H, Takahashi S, Katagiri H, Honda H, Kiyonari H, Uchida T, Asano T.

Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit.

J. Biol. Chem. 290: 24255-66. 2015

 

Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Asano T.

DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.

Am. J. Physiol. Endocrinol. Metab. 309: E214-23. 2015

 

Nakatsu Y, Seno Y, Kushiyama A, Sakoda H, Fujishiro M, Katasako A, Mori K, Matsunaga Y, Fukushima T, Kanaoka R, Yamamotoya T, Kamata H, Asano T.

The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.

Am. J. Physiol. Gastrointest Liver Physiol. 309: G42-51. 2015

 

Fukushima T, Yoshihara H, Furuta H, Kamei H, Hakuno F, Luan J, Duan C, Saeki Y, Tanaka K, Iemura S, Natsume T, Chida K, Nakatsu Y, Kamata H, Asano T, Takahashi S.

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.

Nat. Commun. 6: 6780. 2015

 

Okubo H, Nakatsu Y, Sakoda H, Kushiyama A, Fujishiro M, Fukushima T, Matsunaga Y, Ohno H, Yoneda M, Kamata H, Shinjo T, Iwashita M, Nishimura F, Asano T.

Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model.

Am. J. Physiol. Gastrointest Liver Physiol. 308: G151-8. 2015

 

Qiang S, Nakatsu Y, Seno Y, Fujishiro M, Sakoda H, Kushiyama A, Mori K, Matsunaga Y, Yamamotoya T, Kamata H, Asano T.

Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus.

Diabetol. Metab. Syndr. 7: 104. 2015

 

Matsunaga Y, Nakatsu Y, Fukushima T, Okubo H, Iwashita M, Sakoda H, Fujishiro M, Yamamotoya T, Kushiyama A, Takahashi S, Tsuchiya Y, Kamata H, Tokunaga F, Iwai K, Asano T.

LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.

Mediators Inflamm. 2015: 125380. 2015

 

Kanaoka R, Kushiyama A, Seno Y, Nakatsu Y, Matsunaga Y, Fukushima T, Tsuchiya Y, Sakoda H, Fujishiro M, Yamamotoya T, Kamata H, Matsubara A, Asano T.

Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines.

PLoS One 10: e0127467. 2015

 

Ohba Y,Nakaya M, Watari K, Nagasaka A, Kurose H.

GRK6 phosphorylates IκBα at Ser(32)/Ser(36) and enhances TNF-α-induced inflammation.

Biochem. Biophys. Res. Commun. 461: 307-13. 2015

 

Tobo A, Tobo M, Nakakura T, Ebara M, Tomura H, Mogi C, Im DS, Murata N, Kuwabara A, Ito S, Fukuda H, Arisawa M, Shuto S, Nakaya M, Kurose H, Sato K, Okajima F.

Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses.

PLoS One 10: e0129334. 2015

 

Nagasaka A, Ohba Y, Kurose H, Nakaya M.

Novel functions of GRK6 in macrophages by phosphorylating the non-GPCRs substrates.

Macrophage 2: e1021. 2015

 

Yamagishi S, Yamada K, Sawada M, Nakano S, Mori N, Sawamoto K, Sato K.

Netrin-5 is highly expressed in neurogenic regions of the adult brain.

Front Cell Neurosci. 9: 146. 2015

 

Sakaguchi R, Chikuma S, Shichita T, Morita R, Sekiya T, Ouyang W, Ueda T, Seki H, Morisaki H, Yoshimura A.

Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22. Int Immunol. 28:233-43. 2015

 

Sekiya T, Kondo T, Shichita T, Morita R, Ichinose H, Yoshimura A.

Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells.

J. Exp. Med. 212: 1623-40. 2015

 

Suzuki M, Morita R, Hirata Y, Shichita T, Yoshimura A.

Spred1, a Suppressor of the Ras-ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells.

J. Immunol. 195: 1273-81. 2015

 

Kashiwagi I, Morita R, Shichita T, Komai K, Saeki K, Matsumoto M, Takeda K, Nomura M, Hayashi A, Kanai T, Yoshimura A.

Smad2 and Smad3 Inversely Regulate TGF-β Autoinduction in Clostridium butyricum-Activated Dendritic Cells.

J. Immunity 43: 65-79. 2015

 

Ito M, Shichita T, Okada M, Komine R, Noguchi Y, Yoshimura A, Morita R.

Bruton’s tyrosine kinase (BTK) is an essential component for NLRP3 inflammasome activation and a potential therapeutic target for inflammation after ischemic brain injury.

Nat Commun. 6: 7360. 2015

 

Mi-ichi F, Miyamoto T, Takao S, Jeelani G, Hashimoto T, Hara H, Nozaki T, Yoshida H.

Entamoeba mitosomes play an important role in encystation by association with cholesteryl sulfate synthesis.

Proc. Natl. Acad. Sci. USA 112: E2884-90. 2015

 

Pertuit D, Lotfabad TB, Mitaine-Offer A-C, Miyamoto T, Tanaka C, M.-A. Lacaille-Dubois M-A.

Two new triterpene saponins from acanthophyllum laxiusculum.

Helvetica Chimica Acta, 98: 611-7. 2015

 

Gabriel AF, Li Z, Kusuda R, Tanaka C, Miyamoto T.

Six new polyacetylenic alcohols from the marine sponges Petrosia sp. and Halichondria sp.

Chem. Pharm. Bull. 63: 469-75. 2015

 

Tchegnitegni BT, Teponno RB, Tanaka C, Gabriel AF, Tapongjou LA, Miyamoto T.

Sappanin-type homoisoflavonoids from Sansevieria trifasciata Prain.

Phytochem. Lett. 12: 262-266. 2015

 

Wilson GJ, Marakalala MJ, Hoving JC, van Laarhoven A, Drummond RA, Kerscher B, Keeton R, van de Vosse E, Ottenhoff TH, Plantinga TS, Alisjahbana B, Govender D, Besra GS, Netea MG, Reid DM, Willment JA, Jacobs M, Yamasaki S, van Crevel R, Brown GD.

The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity.

Cell Host Microbe. 17: 252-9. 2015

 

Yamakoshi H, Palonpon A, Dodo K, Ando J, Kawata S, Fujita K, Sodeoka M.

A sensitive and specific Raman probe based on bisarylbutadiyne for live cell imaging of mitochondria.

Bioorg. Med. Chem. Lett. 25:664-7. 2015

 

Lauber S, Wong S, Cutz JC, Tanaka M, Barra N, Lhoták S, Ashkar A, Richards CD.

Novel function of Oncostatin M as a potent tumour-promoting agent in lung.

Int. J. Cancer. 136:831-43. 2015

 

Maekawa Y, Ishifune C, Tsukumo SI, Hozumi K, Yagita H, Yasutomo K.

Notch controls the survival of memory CD4+ T cells by regulating glucose uptake.

Nat. Med. 21:55-61. 2015

 

Watanabe T, Ito T, Gouda H, Ishibashi Y, Miyamoto T, Ikeda K, Taguchi R, Okino N, Ito M.

Sterylglucoside catabolism in cryptococcus neoformans with endoglycoceramidase-related protein 2 (EGCrP2), the first steryl-beta-glucosidase identified in Fungi.

J. Biol. Chem. 290:1005-19. 2015

 

Kanno S, Nishio H, Tanaka T, Motomura Y, Murata K, Ihara K, Onimaru M, Yamasaki S, Kono H, Sueishi K, Hara T.

Activation of an innate immune receptor, nod1, accelerates atherogenesis in apoe-/- mice.

J. Immunol. 194:773-80. 2015

 

Karasawa K, Asano K, Moriyama S, Ushiki M, Monya M, Iida M, Kuboki E, Yagita H, Uchida K, Nitta K, Tanaka M.
Vascular‐resident CD169‐positive monocytes and macrophages control neutrophil accumulation in the kidney with ischemia‐reperfusion injury.
J. Am. Soc. Nephrol. 26: 896-906. 2015

 

Satou M, Enoki H, Oikawa A, Ohta D, Saito K, Hachiya T, Sakakibara H, Kusano M, Fukushima A, Saito K, Kobayashi M, Nagata N, Myouga F, Shinozaki K, Motohashi R.

Integrated analysis of transcriptome and metabolome of Arabidopsis albino or pale green mutants with disrupted nuclear-encoded chloroplast proteins.

Plant Mol Biol. 85:411-28, 2014

 

Tawaraya K, Horie R, Saito S, Wagatsuma T, Saito K, Oikawa A.

Metabolite Profiling of Root Exudates of Common Bean under Phosphorus Deficiency.

Metabolites. 4:599-611, 2014

 

Osanai T, Oikawa A, Iijima H, Kuwahara A, Asayama M, Tanaka K, Ikeuchi M, Saito K, Hirai MY.

Metabolomic analysis reveals rewiring of Synechocystis sp. PCC 6803 primary metabolism by ntcA overexpression.

Environ Microbiol. 16:3304-17, 2014

 

Doe K, Nozawa K, Hiruma K, Yamada Y, Matsuki Y, Nakano S, Ogasawara M, Nakano H, Ikeda T, Ikegami T, Fujishiro M, Kawasaki M, Ikeda K, Amano H, Morimoto S, Ogawa H, Takamori K, Sekigawa I, Takasaki Y.

Antibody against chromatin assembly factor-1 is a novel autoantibody specifically recognized in systemic lupus erythematosus.

Lupus. 23: 1031-41. 2014

 

Egami H, Sodeoka M.

Recent progress on trifluoromethylation of alkenes with concomitant introduction of additional functional groups.

Angew. Chem. Int. Ed. 53: 8294-308. 2014

 

Sakuma C, Kawauchi T, Haraguchi S, Shikanai M, Yamaguchi Y, Gelfand VI, Luo L, Miura M, Chihara T.

Drosophila Strip serves as a platform for early endosome organization during axon elongation.

Nat. Commun. 5: 5180. 2014

 

Yamaguchi Y, Kuranaga E, Nakajima Y, Koto A, Takemoto K, Miura M.

In vivo monitoring of caspase activation using a fluorescence resonance energy transfer-based fluorescent probe.

Methods Enzymol. 544: 299-325. 2014

 

Miyajima A, Tanaka M, Itoh T.

Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming.

Cell Stem Cell 14: 561-74. 2014 Review.

 

Tanaka M, Ikeda K, Suganami T, Komiya C, Ochi K, Shirakawa I, Hamaguchi M, Nishimura S, Manabe I, Matsuda T, Kimura K, Inoue H, Inagaki Y, Aoe S, Yamasaki S, Ogawa Y.

Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis.

Nat. Commun. 5: 4982. 2014

 

Kawai Y, Ouchida R, Yamasaki S, Dragone L, Tsubata T, Wang JY.

LAPTM5 promotes lysosomal degradation of intracellular CD3ζ but not of cell surface CD3ζ.

Immunol. Cell Biol. 92: 527-34. 2014

 

Sato F, Miyaoka Y, Miyajima A, Tanaka M.

Oncostatin M maintains the hematopoietic microenvironment in the bone marrow by modulating adipogenesis and osteogenesis.

PLoS One 9: e116209. 2014

 

Egami H, Shimizu R, Usui Y, Sodeoka M.

Oxy-trifluoromethylation of alkenes and its application to the synthesis of β-trifluoromethylstyrene derivatives.

J. Fluor. Chem. 167: 172-8. 2014

 

Tsukamoto M, Hashimoto D, Chikamoto A, Abe S, Ohmuraya M, Baba H.

Clinical features and management of pancreatic solid pseudopapillary tumor.

Am. Surg. 80: 1212-5. 2014

 

Kusuda T, Nakashima Y, Murata K, Kanno S, Nishio H, Tanaka T, Yamamura K, Sakai Y, Takada H, Hara T, Saito M, Miyamoto T, Mizuno Y, Ouchi K, Waki K.

Kawasaki disease-specific molecules in the sera are linked to microbe-associated molecular patterns in the biofilms.

PLoS One 9: 113054. 2014

 

Thuaud F, Kojima S, Hirai G, Oonuma K, Tsuchiya A, Uchida T, Tsuchimoto T, Sodeoka M.

RE12 derivatives displaying Vaccinia H1-related phosphatase (VHR) inhibition in the presence of detergent and their anti-proliferative activity against HeLa cells.

Bioorg. Med. Chem. 22: 2771-82. 2014

 

Kitamura A, Sasaki A, Abe T, Kano H, Yasutomo K.

An inherited mutation in NLRC4 causes autoinflammation in human and mice.

J. Exp. Med. 211:2385-96. 2014

 

Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh‐hora M, Akashi K, Yamasaki S.
Dectin‐2 is a direct receptor for mannose‐capped lipoarabinomannan of mycobacteria.
Immunity 41:402-13. 2014

 

Ishibashi Y, Nagamatsu Y, Miyamoto T, Matsunaga N, Okino N, Yamaguchi K, Ito M.
A novel ether‐linked phytol‐containing digalactosylglycerolipid in the marine green alga, Ulva pertusa.
Biochem. Biophys. Res. Commun. 452:873-80. 2014

 

Tabopda TK, Mitaine‐Offer AC, Tanaka C, Miyamoto T, Mirjolet JF, Duchamp O, Ngadjui BT, Lacaille‐Dubois MA.
Steroidal saponins from Dioscorea preussii.
Fitoterapia 97: 198‐203. 2014

 

Egami H, Ide T, Fujita M, Tojo T, Hamashima Y, Sodeoka M.
Dual Catalysis with Copper and Rhenium for Trifluoromethylation of Propargylic Alcohols: Efficient Synthesis of α‐Trifluoromethylated Enones
Chem. Eur. J. 20:12061‐5. 2014

 

Sodeoka M, Egami H.
Metal‐catalyzed synthesis of heterocycles bearing a trifluoromethyl group.
Pure & Appl. Chem. 86:1247‐1256. 2014

 

Taguchi K, Okada A, Kitamura H, Yasui T, Naiki T, Hamamoto S, Ando R, Mizuno K, Kawai N, Tozawa K., Asano K., Tanaka M., Miyoshi I, Kohri K.
Colony‐stimulating factor‐1 signaling suppresses renal crystal formation.
J. Am. Soc. Nephrol. 25:1680‐1697. 2014

 

Liu T, Yamaguchi Y, Shirasaki Y, Shikada K, Yamagishi M, Hoshino K, Kaisho T, Takemoto K, Suzuki T, Kuranaga E, Ohara O, Miura M.
Single‐Cell Imaging of Caspase‐1 Dynamics Reveals an All‐or‐None Inflammasome Signaling Response.
Cell Reports 8:974‐82. 2014

 

Shimazu T, Barjau J, Sohtome Y, Sodeoka M, Shinkai Y.
Selenium‐Based S‐Adenosylmethionine Analog Reveals the Mammalian Seven‐Beta‐Strand Methyltransferase METTL10 to Be an EF1A1 Lysine Methyltransferase.
PLoS One 9:e105394. 2014

 

Yagai T, Miyajima A, Tanaka M.
Semaphorin 3E secreted by damaged hepatocytes regulates the sinusoidal regeneration and liver fibrosis during liver regeneration.
Am. J. Pathol. 184:2250‐9. 2014

 

Miyamoto T, Okimoto T, Kuwano M.
Chemical Composition of the Essential Oil of Mastic Gum and their Antibacterial Activity Against Drug‐Resistant Helicobacter pylori.
Nat. Prod. Bioprospect. 4:227‐31. 2014

 

Ohgane K, Karaki F, Noguchi‐Yachide T, Dodo K, Hashimoto Y.
Structure‐activity relationships of oxysterol‐derived pharmacological chaperones for Niemann‐Pick type C1 protein.
Bioorg. Med. Chem. Lett. 24: 3480‐5. 2014

 

Yamaguchi T, Asanuma M, Nakanishi S, Saito Y, Okazaki M, Dodo K, Sodeoka M.
Turn‐ON fluorescent affinity labeling using a small bifunctional O‐nitrobenzoxadiazole unit: selective labeling and imaging of target protein.
Chem. Sci. 5:1021‐1029. 2014

 

Giordano M, Roncagalli R, Bourdely P, ChassonL, Buferne M, Yamasaki S, Beyaert R, van Loo G, Auphan‐Anezin N, Schmitt‐Verhulst AM, Verdeil G.
The tumor necrosis factor alpha‐induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells.
Proc. Natl. Acad. Sci. USA 111: 11115‐20. 2014

 

Karaki F, Ohgane K, Fukuda H, Nakamura M, Dodo K, Hashimoto Y.
Structure‐activity relationship study of non‐steroidal NPC1L1 ligands identified through cell‐based assay using pharmacological chaperone effect as a readout.
Bioorg. Med. Chem. 22: 3587‐609. 2014

 

Phongsisay V, Iizasa E, Hara H, Yamasaki S.
LMIR5 extracellular domain activates myeloid cells through Toll‐like receptor 4.
Mol Immunol. 62: 169‐77. 2014

 

Hashimoto D, Chikamoto A, Ohmuraya M, Sakata K, Miyake K, Kuroki H, Watanabe M, Beppu T, Hirota M, Baba H.
Pancreatic cancer in the remnant pancreas following primary pancreatic resection.
Surg. Today 44: 1313‐20. 2014

 

Hashimoto D, Chikamoto A, Ohmuraya M, Hirota M, Baba H.
Pancreaticodigestive anastomosis and the postoperative management strategies to prevent postoperative pancreatic fistula formation after pancreaticoduodenectomy.
Surg. Today 44: 1207‐13. 2014

 

Miyazaki A, Asanuma M, Dodo K, Egami H, Sodeoka M.
A “catch‐and‐release” protocol for alkyne‐tagged molecules based on a resin‐bound cobalt complex for peptide enrichment in aqueous media.
Chem. Eur. J. 20:8116‐28. 2014

 

Pertuit D, Avunduk S, Mitaine‐Offer AC, Miyamoto T, Tanaka C, Paululat T, Delemasure S, Dutartre P, Lacaille‐Dubois MA.
Triterpenoid saponins from the roots of two Gypsophila species.
Phytochemistry 102:182‐8. 2014

 

Honda S, Arakawa S, Nishida Y, Yamaguchi H, Ishii E, Shimizu S.
Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes.
Nature Commun. 5:4004. 2014

 

Hattori Y, Morita D, Fujiwara N, Mori D, Nakamura T, Harashima H, Yamasaki S, Sugita M.
Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C‐type lectin, mincle.
J. Biol. Chem. 289:15405‐12. 2014

 

Nagashima H, Okuyama Y, Asao A, Kawabe T, Yamaki S, Nakano H, Croft M, Ishii I, So T.
The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL‐6.
Nat. Immunol. 15:449‐56. 2014

 

Komori T, Tanaka M, Senba E, Miyajima A, Morikawa Y.
Deficiency of Oncostatin M receptor b (OSMRβ) exacerbates high‐fat diet‐induced obesity and related metabolic disorders in mice.
J. Biol. Chem. 289:13821‐37. 2014

 

Thuaud F. Kojima S. Hirai G. Onnuma K, Tsuchiya A, Uchida T, Tsuchimoto T, Sodeoka M.
RE12 derivatives displaying Vaccinia H1‐related phosphatase (VHR) inhibition in the presence of detergent and their anti‐proliferative activity against HeLa cells.
Bioorg. Med. Chem. 22:2771‐82. 2014

 

Manase MJ, Mitaine‐Offer AC, Miyamoto T, Tanaka C, Delemasure S, Dutartre P, Lacaille‐Dubois MA.
Triterpenoid saponins from Polycarpaea corymbosa Lamk. Var. eriantha Hochst
Phytochemistry 100: 150‐5. 2014

 

Ishifune C, Maruyama S, Sasaki Y, Yagita H, Hozumi K, Tomita T, Kishihara K, Yasutomo K.
Differentiation of CD11c+CX3CR1+ cells in the small intestine requires Notch signaling.
Proc. Natl. Acad. Sci. USA 111:5986‐91. 2014

 

Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, Sansoni A, Kanduri K, Joly R, Malzac A, Lahdemaki H, Lahesmaa R, Yamasaki S, Saito T, Mallisen M, Aebersold R, Gstaiger M, Malissen B.
Quantitative proteomic analysis of signalosome dynamics in primary T cells identifies the CD6 surface receptor as a LAT‐independent TCR signaling hub.
Nat. Immunol. 15:384‐92. 2014.

 

Ravishankar B, Shinde R, Liu H, Chaudhary K, Bradley J, Lemos HP, Chandler P, Tanaka M, Munn DH, Mellor AL, McGaha TL.
Marginal zone CD169+ macrophages coordinate apoptotic cell‐driven cellular recruitment and tolerance.
Proc. Natl. Acad. Sci. USA 111: 4215‐20. 2014

 

Ozaki N, Fukuchi Y, Tomiyoshi S R, Uehara H, Ida S, Wang J, Araki K, Sibilia M, Baba H, Yamamura K, Ohmuraya M.
Autophagy regulation in pancreatic acinar cells is independent of epidermal growth factor receptor signaling.
Biochem. Biophys. Res. Commun. 446: 224‐30. 2014

 

Nakagawa Y, Sakuma T, Nakagata N, Yamasaki S, Takeda N, Ohmuraya M, Yamamoto T.
Application of Oocyte Cryopreservation Technology in TALEN‐Mediated Mouse Genome Editing.
Exp. Anim. 63: 349‐55. 2014

 

Taguchi K, Hirano I, Itoh T, Tanaka M, Miyajima A, Suzuki A, Motohashi H, Yamamoto M.
Nrf2 enhances cholangiocyte expansion in Pten‐deficient livers.
Mol. Cell. Biol. 34:900‐13. 2014

 

Bhuyan ZA, Asanoma M, Iwata A, Ishifune C, Maekawa Y, Shimada M, Yasutomo K.
Abrogation of Rbpj attenuates experimental autoimmune uveoretinitis by inhibiting IL‐22‐producing CD4+ T cells.
PLoS One 9:e89266. 2014

 

Yamakoshi H, Phlonpon AF, Dodo K, Ando J, Kawata S, Fujita K, Sodeoka M.
Simultaneous imaging of protonated and deprotonated carbonylcyanide p‐trifluoromethoxyphenylhydrazone in live cells by Raman microscopy.
Chem. Commun. 50:1341‐3. 2014

 

Toyonaga K, Miyake Y, Yamasaki S.
Characterization of the Receptors for Mycobacterial Cord Factor in Guinea Pig.
PLoS One 9:e88747. 2014.

 

Bian Z, Dai J, Nakano H, Guan H, Yuan Y, Gan L, Zhou H, Zong J, Zhang Y, F. F, Yan L, Shen D, Li H, Tang Q.
Disuption of Tumor Necrosis Factor Receptor Associated Factor 5 Exacerbates Pressure Overload Cardiac Hypertrophy and Fibrosis.
J. Cell. Biochem. 115:349‐58. 2014

 

Nakagawa Y, Yamamoto T, Suzuki K, Araki K, Takeda N, Ohmuraya M, Sakuma T.
Screening methods to identify TALEN‐mediated knockout mice.
Exp. Anim. 63: 79‐84. 2014

 

Ashour A, El‐Sharkawy S, Amer M, Abdel Bar F, Katakura Y, Miyamoto T, Toyota N, Bang TH, Kondo R, Shimizu K.
Rational design and synthesis of topoisomerase I and II inhibitors based on oleanolic acid moiety for new anti‐cancer drugs.
Bioorg Med Chem. 22: 211‐20.2014

 

Sakata K, Ohmuraya M, Araki K, Suzuki C, Ida S, Hashimoto D, Wang J, Uchiyama Y, Baba H, Yamamura K.
Generation and analysis of serine protease inhibitor kazal type 3‐cre driver mice.
Exp. Anim. 63: 45‐53. 2014